Interestingly, Wang and colleagues determined that hypoxia-responsive polymer micelles such as methoxyl poly (ethylene glycol)-co-poly(aspartate-nitroimidazole) synergically act with a NQO1 inhibitor (dicoumarol) to sensitize SKOV3 ovarian cancer cell line to the anticancer agent sorafenib under low oxygen conditions. The gene discussed is NQO1; the disease is ovarian carcinoma.