No statistically significant differences in terms of CD4/CD8 ratio changes were found when comparing different clinical (UCD vs. MCD (as a whole), p = 0.2275; UCD vs. iMCD vs. HHV8+MCD, p = 0.2232); histological (CD HV vs. CD HyperV vs. CD mixed vs. CD PC, p = 0.7899); and clinico-pathological subtypes of CD (HV UCD vs. mixed UCD vs. HyperVMCD vs. mixed MCD vs. PC MCD, p = 0.2039) (Figure 2). Here, CD8A is linked to urea cycle disorder.