This more than 11-fold increase in incidence compared to the general population may be explained by the late age of the patients and the relatively small size of the cohort; however, we observed an association of their presence with high-grade tumours (they were present in 3 of the 5 G3 patients, while 1 of the remaining 2 patients carried the TET2 mutation in the ctDNA). The gene discussed is TET2; the disease is neoplasm.