HFE and hypertensive disorder: The significant role of gene–environment interactions (SNPs with smoking, alcohol intake) in the nature of candidate gene polymorphism associations with HTN, including those considered in this work ARHGAP42 rs633185 C > G, HFE rs1799945 C > G, AC026703.1 rs1173771 G > A was shown in previously conducted GWAS [9,10,65].