These are genes such as HLA system (HLA-DRB6; HLA-DRB5; HLA-DRB1; HLA-DQA1; HLA-S; HLA-B), HSP (heat shock protein:HSPA1A; HCP5; HSPA1B), LY6 (lymphocyte antigen 6:LY6G5C; LY6G5B; LY6G6C; LY6G6E; LY6G6D; LY6G6F), etc., the expression/splicing of which is regulated by HTN-associated polymorphisms in various organs, including those that are targets for disease (heart/aorta/coronary and other arteries). This evidence concerns the gene HLA-DRB5 and hypertensive disorder.