The tissue-specific SNP-splicing associations were recognized for five HTN-causal loci [CERS5 rs7302981 G > A, HFE rs1799945 C > G, OBFC1 rs4387287 C > A, BAG6 rs805303 G > A, TBX2 rs8068318 T > C] and 65 of 96 proxies SNPs (67.71%) in men and six HTN-causal polymorphisms [CERS5 rs7302981 G > A, HFE rs1799945 C > G, OBFC1 rs4387287 C > A, BAG6 rs805303 G > A, TBX2 rs8068318 T > C, ATP2B1 rs2681472 A > G] and 67 out 125 linked loci (53.60%) in women (Tables S11 and S12). This evidence concerns the gene TBX2 and hypertensive disorder.