The results of the MDR analysis showed that the greatest contribution to the HTN susceptibility in men was made by two-gene/locus synergetic interactions HFE (rs1799945)–TBX2 (rs8068318) (0.76% of HTN entropy), CERS5 (rs7302981)–RGL3 (rs167479) (0.64%), CERS5 (rs7302981)–BAG6 (rs805303) (0.49%), BAG6 (rs805303)–AC026703.1 (rs1173771) (0.46%), HFE (rs1799945)–AC026703.1 (rs1173771) (0.46%) (Figure 1). Here, RGL3 is linked to hypertensive disorder.