For example, among HTN-causal SNPs with gene transcription in the heart have been associated rs1799945 (HIST1H3E), rs805303 (LY6G5B, HLA-DRB5, DDAH2, CSNK2B, C4A, CYP21A1P), rs633185 (ARHGAP42, TMEM133), rs7302981 (RP4-605O3.4, CERS5), rs2681472 (RP11-981P6.1), rs8068318 (TBX2-AS1, TBX2) (Table S9). This evidence concerns the gene C4A and hypertensive disorder.