According to the in silico study results, the locus (with ten proxy SNPs) is the major regulator (the so—called “master regulator”) of epigenetic/expression/splicing traits at fifty-five genes, including immune system genes (e.g., HLA, LY6, HSP gene clusters) which strongly correlated with HTN [84,85,86,87,88] (detailed information about the connection of the immunity-importance above-mentioned genes with HTN is given below). Here, HSP90B2P is linked to hypertensive disorder.