The connection of several HTN-causal genes/loci such as AC026703.1 rs1173771 G > A, CERS5 rs7302981 G > A, OBFC1 rs4387287 C > A, BAG6 rs805303 G > A with the DNA epigenetic modifications characteristic of promoters (H3K4me3/H3K9ac) and enhancers (H3K4me1/H3K27ac) in disorder target organs—heart (fetal [rs4387287; rs7302981] and adult [rs1173771; rs805303; rs4387287; rs7302981]), aorta [rs4387287], is very interesting and important for understanding the involvement of the investigated polymorphisms in the HTN pathophysiology. The gene discussed is CERS5; the disease is hypertensive disorder.