Cooperation between genes such as HLA-DQB1—HLA-DQA1, CSNK2A1—CSNK2B, LSM3—LSM2, demonstrated the very strong contribution (their weight coefficient was maximum and equal to 1) to the HTN susceptibility in both men (Table S15) and women (Table S16). This evidence concerns the gene HLA-DQA1 and hypertensive disorder.