PLCE1 and hypertensive disorder: In women, the HTN predisposition was determined by the strongly pronounced influence of three two-gene/locus synergetic interactions TBX2 (rs8068318)–RGL3 (rs167479) (2.26%), PLCE1 (rs932764)–CERS5 (rs7302981) (1.31%) and CERS5 (rs7302981)–BAG6 (rs805303) (1.06%) (Figure 2).