The downregulated C-C motif chemokine ligand 20 (CCL20) in NRP-1 KO cells was also studied in taxane-containing chemotherapy in triple-negative breast cancer (TNBC), and the elevated levels of CCL20 were shown to stimulate breast cancer stem-like cells through protein kinase C (PKC) [40]. This evidence concerns the gene PRRT2 and breast cancer.