Although Collagen Alpha-3 (VI) COL6A3 was shown to enhance brain metastasis in breast cancer patients [39], COL6A3 was upregulated in NRP-1 KO cells which showed less metastatic lesions to the lungs; future gain and loss of function studies will reveal more information about the actual role of this gene. The gene discussed is COL6A3; the disease is breast cancer.