In a high-fat diet T2DM mice model, exendin-4 protected against heart remodeling and attenuated the levels of IL-1β, IL-6, TNF-α, ICAM-1, and VCAM-1 by inhibiting NLRP3 inflammasome-dependent inflammatory pathways [66,67]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.