Previous studies showed that silencing ZKSCAN3 by small hairpin RNAs (shRNAs) in bladder cancer cells (UC13) can promote senescence of them [5], which may be due to the degradation of lamin B1 via autophagy, a type of selective autophagy—nuclear autophagy [15,16,17]. The gene discussed is LMNB1; the disease is urinary bladder cancer.