Several genes have been identified as playing a role in the genetics of HTN such as Sodium Channel Epithelial 1 subunits (SCNN1A, SCNN1B, SCNN1C) and recently reported SCNN1D [155], Armadillo Repeat Containing 5 (ARMC5), G Protein-Coupled Receptor Kinase 4 (GRK4) and Calcium Voltage-Gated Channel Subunit A1 D (CACNA1D) [156]. Here, GRK4 is linked to hypertensive disorder.