To further confirm these results, we performed apoptosis assays, observing that miR-19b reduces 5-FU-induced apoptotic effects in a PPP2R5E-dependent manner (Figure S12), which reinforces the role of the miR-19b/PPP2R5E signaling axis regulating 5-FU antitumor effects in CRC cells. Here, PPP2R5E is linked to colorectal carcinoma.