Flow cytometry analysis of papillomas showed generally low immune cell infiltration in both genotypes; however, CD11b+ myeloid cells and pro-tumor PMN-MDSCs trended higher in the knockout mice, which was corroborated by higher IL-6 (produced by myeloid cells) mRNA expression in CB2-/- papillomas (Figure 5A–C). The gene discussed is CNR2; the disease is neoplasm.