CNR2 and skin neoplasm: When comparing the expression and activation levels of various proangiogenic factors in untreated and cannabinoid-treated skin cancers, these factors were significantly reduced in cannabinoid-treated tumors compared to vehicle-treated tumors, supporting the idea that the anti-tumorigenic actions of CB2 are mediated at least in part by the activation of CB2 signaling in skin tumor cells [52,64].