PON1 and coronary artery disorder: In a case-control study, angiographically confirmed CAD patients (n = 105) had significantly increased levels of plasma 8-isoprostane F2 (8-iso-PGF2α, produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids) and reduced paraoxonase and arylesterase activities of PON1 compared to healthy controls (n = 45) [45].