The PON1 rs854560 allele T was associated with dyslipidemia (p = 0.014) and increased risk of ischemic cerebral stroke (OR 1.38, 1.02–1.85, p  =  0.034), while the PON1 rs705379 TT variant was associated with CVD mortality (HR 1.27, 95% CI 1.03–1.57, p  =  0.025), while PON1 rs662 was not. This evidence concerns the gene PON1 and metabolic syndrome.