PON1 and coronary artery disorder: Although the distinct single nucleotide polymorphisms (SNPs, including Q192R) within the PON1 gene, identified by a genome-wide association study, were highly significantly associated with serum paraoxonase (p = 1.2 × 10−303) and arylesterase (p = 5.0 × 10−116) activity, these variants were not associated with future risk of MACE in an angiographic cohort (n = 2136), consistent with analyses from the CARDIoGRAM consortium, which did not show any association of these SNPs with history of prevalent CAD or MI in ≈80 000 subjects.