APOE and Alzheimer disease: Another study evaluated LDL oxidation in late-onset AD patients (n = 54, 77-year-old, 19% male, MMSE score = 18) and healthy elderly subjects (n = 51, 77-year-old, 27% male, MMSE score = 29) and its interaction with PON1-107C/T and apolipoprotein E (APOE) genotypes [88].