ARHGAP11A was found to be the only independent risk factor for ccRCC (Figure 1B,C, univariate analysis: hazard ratio (HR) 1.799, 95% confidence interval (CI) 1.328–2.437; multivariate analysis: HR 1.949, 95% CI 1.364–2.785). The gene discussed is ARHGAP11A; the disease is nonpapillary renal cell carcinoma.