Importantly, major adipocytokines that are implicated in antioxidant effects, anti-inflammatory activity and insulin sensitivity in the cardiovascular system and are observed to circulate at lower levels in obesity, such as omentin-1 and adiponectin [86,87,88], have been reported to be enclosed in EVs derived from WAT [89]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.