IGF1R and Insulin resistance: In addition, miR-802-5p enriched in EVs from cultured hypertrophic adipocytes has been reported to contribute to cardiac insulin resistance [77], most likely through the downregulation of HSP60, which has been shown to regulate Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling and be inversely correlated with diabetic cardiomyopathy [99].