AKT1 and non-small cell lung carcinoma: In addition to the aforementioned Wnt/β-catenin pathway, numerous studies have shown that multiple signaling pathways are also involved in the regulation of EMT, such as the study by Wang et al. [84], which found that sotetsuflavon reversed the inhibition of invasion and metastasis of non-small cell lung cancer A549 cells by EMT through TNF-α/NF-κB and PI3K/AKT signaling pathways.