That is, ethanol could deplete the levels of methyl-donors (folate acid and methionine) in SiHa cells or mouse tumor-bearing tissue and activate the mRNA expression levels of DNMT family members (DNMT 1, DNMT 3a, DNMT 3b, and Mecp), resulting in a hypomethylation status of cervical cancer (Figure 8). The gene discussed is DNMT1; the disease is neoplasm.