BCHE and Alzheimer disease: In our previous work, a number of novel 2-alkyl derivatives of 1,2,3,4-tetrahydrochromeno[3,2-c]pyridin-10-one (1, Scheme 1), bearing different substituents at C6 and C8, were synthesized and characterized as MTDLs against MAOs A and B, AChE and BChE, which are targets of drugs alleviating the symptoms of neurodegenerative dementias, including AD.