In an article previously published by our group [13], it was observed when comparing patients with Down syndrome with periodontal disease (DS+PD+) to patients with Down syndrome without periodontal disease (DS+PD−) that despite suffering from the same syndromic condition, both groups did not show the same susceptibility to periodontal disease, instead showing differential expression of TNFSF13B, ITGB2, ANXA5 and ANXA3, of the 92 inflammation-related genes presented in the TaqManTM Array Plate Human Inflammation Kit (Thermo Fisher Scientific, Waltham, MA, USA). The gene discussed is ANXA3; the disease is periodontal disorder.