A series of genetic studies has uncovered that the gain-of-function mutations in the genes encoding aldosterone synthase, MR, and ENaC uniformly drive blood pressure to high levels [27,28,29], whereas the loss-of-function mutations in the same genes all cause hypotensive disorders [30,31,32,33,34], highlighting the predominant role of the aldosterone/MR system in regulating blood pressure in humans [26]. This evidence concerns the gene NR3C2 and hypotensive disorder.