EGF and colorectal carcinoma: To understand the underlying regulatory mechanisms, Li and his colleagues (2013) provided remarkable data showing that human epidermal growth factor (hEGF) can up-regulate the expression of AQP3 protein and the migration ability of the human colorectal carcinoma cell line HCT-116 in a dose- and time-dependent manner whereas an AQP3 inhibitor, CuSO4, blocked the enhanced migration ability of HCT-116 cells.