In 2021, Dirir et al. reviewed the AGS inhibitory activity of 290 plant-derived natural products discovered between the year 2015 and 2020 and identified eight molecules, i.e., taxumariene F, akebonoic acid, morusin, rhaponticin, procyanidin A2, alaternin, mulberrofuran K, and psoralidin, as potent AGS inhibitors and promising drug candidates for the treatment of T2DM [15]. This evidence concerns the gene JAG1 and type 2 diabetes mellitus.