These findings are in agreement with the protective and anti-inflammatory activities of this potent FXR agonist and they allow us to propose that fluorescence has an ability to monitor the changes in fluorescing fatty acids, arachidonic acid in particular, as a supportive tool of pharmacological studies in hepatology, although additional studies should be performed with other substances and in other models of liver diseases. The gene discussed is NR1H4; the disease is liver disorder.