Tumor-derived EVs carrying cell death receptors and their ligands can induce apoptosis on T cells by activating caspases 3 and 7 [101,102]; additionally, tumor-derived EVs can decrease the synthesis of TNF-α and Interferon gamma (IFN-γ) via Tc cells in a dose-dependent manner [103]. This evidence concerns the gene CASP3 and neoplasm.