In this regard, the generation of EVs derived from HEK 293 cells transfected to express anti-CD3-anti-HER2 bispecific single-chain variable fragment (scFv) antibodies on their surface has facilitated the interaction between HER2-expressing breast cancer cells with CD3-expressing T cells; this interaction efficiently activates T cells, induces the apoptosis of tumor cells and causes the inhibition of tumor growth in an in vivo model associated with the increased infiltration of T cells [158]. Here, ERBB2 is linked to breast cancer.