Several studies have proven that tumor-derived EVs can promote angiogenesis by delivering growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and angiopoietin 1 [65]; miRNAs such as miR-9 [66], miR-23a [67], miR-135b [68,69], miR-494 [70], miR-1246 [71] and miR-210 [72]; lncRNAs such as H19 [73], MALAT1 [74], CCAT2 [75] and POU3F3 [76] and proteins such as Wnt4, which activates the β-catenin pathway in endothelial cells [77,78]. This evidence concerns the gene VEGFA and neoplasm.