Moreover, tumor-derived EVs impair lymphocyte function, since they carry different immunosuppressive molecules such as death receptor Fas, Fas ligand (FasL), TNF-α, TNF-Related Apoptosis-Inducing Ligand (TRAIL), Cytotoxic T Lymphocyte Antigen 4 (CTLA-4), Programed Cell Death Protein 1 (PD-1), PD-L1, CD39 and CD73. This evidence concerns the gene TNF and neoplasm.