CD274 and neoplasm: In line with this approach, colorectal cancer cells treated with starved tumor-cell-derived EVs loaded with miR-34a showed the inhibition of both proliferation and migration, accompanied by apoptosis, via the downregulation of IL-6R, STAT3, PD-L1 and VEGF-A expression in vitro, with prolonged survival time and impaired immune evasion in a solid tumor [122,123].