RN7SL1 loaded in CAR T-cell-derived EVs promotes the maturation of peripheral DCs, increasing the expression of MHC class II and co-stimulatory molecules, and also restricting the development of MDSCs and downregulating the expression of TGF-β, enhancing tumor cell death via CAR-T cells and tumor-specific endogenous T cells [159]. This evidence concerns the gene TGFB1 and neoplasm.