Therefore, the recognition of tumor-derived EVs has been enhanced by the addition of high-glycans as sialic acid on their surface, promoting their capture by DCs via the Dendritic-Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN) receptor, inducing the increased processing of tumor antigens and their expression on MHC class I and II molecules [136,137]. This evidence concerns the gene CD209 and neoplasm.