Several miRNAs carried by tumor-derived EVs can induce the M2 polarization, such as miR124, by inhibiting the TLR4 signaling transduction [89]; likewise, miR-934 [90] and miR-27a-3p upregulate Programed Cell Death Ligand 1 (PD-L1) expression by inhibiting the Phosphatase and Tensin homolog (PTEN) activity on the Phosphatidylinositol 3-Kinase (PI3K)-Akt signaling pathway. The gene discussed is TLR4; the disease is neoplasm.