FAP and melanoma: This is the case for CAFs, which have been targeted via the expression of fibroblast activation protein α (FAP-α), where tumor-derived EVs loaded with tumor antigens and expressing FAP-α induce the maturation of DCs, increasing the infiltration of specific T cells against tumor cells and FAP-positive fibroblasts, and reducing the proportion of M2-TAMs, MDSCs and Treg cells in the in vivo tumor models of murine colon carcinoma, melanoma, Lewis lung carcinoma and breast cancer, with a mechanism associated with the induction of tumor cell ferroptosis and IFN-γ synthesis [145].