Additionally, tumor-derived EVs containing lnc-TALC can promote the M2 polarization of microglia by increasing the expression of Arginine-1 (Arg-1) and CD163, as well as M2-related cytokines (TGF-β, IL-4 and IL-10), via p38 of the MAPK pathway activation [88]. Here, IL10 is linked to neoplasm.