Ethyl acetate fraction (AcL3) of Annona coriacea enriched with acetogenins are highly cytotoxic, prevent cell migration and MMP-2 activation, possibly due to their metal ion chelating properties, and may also induce necroptosis possibly by blocking complex I of the electron transport chain, increasing ROS production, leading to AIF translocation and necroptosome formation, triggering necroptosis on GBM cells. The gene discussed is MMP2; the disease is glioblastoma.