The ethanolic extract of the bark Tabebuia impetiginosa inhibits the production of IL-1β and IL-6 in human peripheral blood mononuclear cells (PBMCs) activated by phorbol myristate acetate (PMA)/ionomycin [36], which agrees with the results observed for the ethanolic extract of T. rosea. An increase in Il1b mRNA expression was observed in orlistat-treated animals compared to SD-Sn and HF-Ob, a result similar to that reported in orlistat-treated high-fat diet obese mice [37]. Here, IL1B is linked to hydrops fetalis.