Il1b and Il18 lead to an inflammatory state, as observed in this study, since Il1b, Il18, Il6, Lep, and Hif1a were found to be overexpressed in the HF-Ob group, a pro-inflammatory process that is predominantly activated by IL-1β, and the treatments induced the downregulation of all of these. The gene discussed is LEP; the disease is hydrops fetalis.