MAPK8 and neoplasm: The anti-tumor mechanism of HM475 may be similar to that of honokiol, activating related apoptosis proteins such as related caspase-3, caspase-9 and Bcl-2, thereby inducing caspase multi-pathway apoptosis, and inhibiting tumor cells and inducing its apoptosis through signal transduction pathways such as MEK, p38-MAPK and JNK signaling pathways.