CASP3 and neuroblastoma: To further investigate the neuroprotective effects of CUR and THC, Maiti et al. [99] measured protein kinase B (Akt) and caspase-3 levels in Aβ42-treated SH-SY5Y neuroblastoma cell cultures and observed that both CUR and THC (1 mmol/L) significantly reduced caspase-3 levels and caused an increase in the level of Akt, suggesting that both compounds may prevent apoptotic death (Figure 5).