Participating in growth, proliferation, apoptosis, migration, invasion, angiogenesis, and many other processes, MMP-9 is confirmed to enroll in a variety of situations clinically, such as tumors [2,3], respiratory diseases [4,5], cardiovascular diseases [6,7], cerebrovascular diseases [8,9], psychiatric disorders [10,11], ophthalmic diseases [12], autoimmune diseases [13] and so on. Here, MMP9 is linked to autoimmune disease.