Celecoxib is a cyclooxygenase-2 (COX-2) selective suppressor that exhibits anti-tumor potential in various types of tumors, such as intestinal cancer, skin cancer, and breast cancer, and anti-inflammatory potential in various types of arthritis such as osteoarthritis, rheumatoid arthritis, and musculoskeletal arthritis. This evidence concerns the gene PTGS2 and skin neoplasm.