AR and prostate carcinoma: The Au-AR pep-PROTAC was found to stimulate the degradation of AR and AR-V7 and reduce the growth of AR- and AR-V7-positive prostate cancer cell lines, including LNCaP, C4-2, and CWR22Rv1, with IC50 values of 230.8 nM, 248.1 nM, and 126.9 nM, respectively.