In the MI group, the activities of NOS, cNOS and NO level significantly decreased (Figure 6H–J, p < 0.01, p < 0.001), and the contents of BNP, IL-6 and TNF-α significantly increased (Figure 6K–M, p < 0.001) relative to the sham group. Here, NOS3 is linked to myocardial infarction.