Mangiferin 16 (Table 1, entry 16)—an isolate of peels and kernels of mango fruits and bark—has been investigated for the treatment of bleomycin-induced PF through inhibiting toll-like receptor protein (TLR4)/p65 and the TGF-β1/Smad2/3 pathway [56]. The gene discussed is SMAD2; the disease is pemphigus foliaceus.