In 2020, in a study that included 34 patients with RA and 41 patients with OA, Wu Y et al. reported increased levels of both VEGF and MMP-13 in synovial fluid and tissue of patients with RA, significantly higher than in patients with OA, as well as a positive correlation between VEGF and MMP-13 [73]. The gene discussed is VEGFA; the disease is rheumatoid arthritis.