By comparing the ROC curves for the seven parameters analyzed (Table 4), we can observe that the best differentiation of patients with moderate disease activity of RA can be obtained using PDUS (100.00% accuracy), followed by VEGF (97.80% accuracy), MMP-13 (71.50% accuracy), and IL-6 (71.10% accuracy). The gene discussed is IL6; the disease is rheumatoid arthritis.