STAT3 and diffuse large B-cell lymphoma: However, in the most recent studies, STAT-3 activity was also associated with advanced stage (stage III/IV), multiple extra-nodal sites involvement, the advanced age of the patient, the presence of B symptoms (presence of fever, weight loss, night sweat), bone marrow involvement, bulky lymph nodes, and a poor prognosis in DLBCL [11,18,25].