Across all tumor types, TP53 was the most commonly altered gene (61%), followed by KRAS (20%), CDKN2A (20%), TERT (16%), APC (16%), PTEN (14%), PIK3CA (14%), CDKN2B (14%), MTAP (10%), and EGFR (10%) (Figure 3A). The gene discussed is APC; the disease is neoplasm.