CEP55 can also activate the PI3K/AKT pathway as an oncogenic mechanism in hepatocellular carcinoma [38], and through the same mechanism, CEP55 was found to activate the proliferation of human glioma U251 cells [39], osteosarcoma [40], and esophageal squamous cell carcinoma [41]. Here, CEP55 is linked to esophageal squamous cell carcinoma.