When addressing the specific prognostic value based on allelic status, many studies have supported that any loss of CDKN2A/2B tumor-suppressor genes may serve as an adverse prognostic marker [17,19,21,26,29], with others disputing the independent prognostic significance in the case of heterozygosity and coexisting aberrations [25,30,32,33,34]. Here, CDKN2A is linked to neoplasm.