The grading system was proposed by ENETS [23,24] and recommended by the WHO in 2010 and is represented by the grade of differentiation of tumor cells on the basis of the mitotic count (at a high power field HPF) and the Ki67% index, using the MIB1 monoclonal antibody staining applied to histological or cytological specimens. This evidence concerns the gene MKI67 and neoplasm.