Importantly, in the etiology of neurodegenerative disorders (the “taupathies”), the affinity of tau proteins for microtubules depends on the degree of their phosphorylation—higher levels of tau protein phosphorylation lead to filamentous degeneration and pathological tau aggregations as neurofibrillary tangles, which correlate with the severity of disorders such as AD [31,32,33,34]. This evidence concerns the gene MAPT and Alzheimer disease.