The endothelial growth factor increases their production, and studies suggest that this contributes to smooth muscle migration in angiogenesis [80].VEGF has also been confirmed to increase the expression of disintegrin and metalloproteinase (ADAM)-33, a factor that plays a significant role in the pathophysiology of asthma, as well as the proliferation of airway smooth muscle cells through activation of the VEGFR2/ERK1/2 pathway [81]. The gene discussed is KDR; the disease is asthma.