It was demonstrated that defects in the autophagy process by knocking out the ATG7 gene in germ cells led to infertility with respect to abnormal acrosome formation, which resulted in round-headed sperm, proving the importance of autophagy and the requirement of ATG7 in acrosome biogenesis during spermatogenesis in mice [125,128]. This evidence concerns the gene ATG7 and Infertility.