We here report on three MFM-filaminopathy patients from two families with novel truncating variants in FLNC: one in exon 30 that encodes part of Ig-like domain 15, and the other in exon 48 encoding the carboxyterminal part of dimerization domain 24 of FLNc. The gene discussed is FLNC; the disease is myofibrillar myopathy 5.