For instance, PGM2, MDH1, and RPIA were present in the NETome of PMA-stimulated HC neutrophils, which are essential for glycolysis, TCA cycle, and the pentose phosphate pathway (PPP), respectively, while IDH1 and MDH2, both essential to the TCA cycle pathway, were identified in the NETome of PMA-stimulated T1D neutrophils. Here, MDH2 is linked to type 1 diabetes mellitus.