Interestingly, target prediction analysis showed that BCL2-L1 is a predicted target for miR-195-5p and miR-202-3p (Table S4) and, to confirm that the axis miR-195-5p/Bcl2-L1 is involved in the sensitization of melanoma cells through EVs, we evaluated BCL2-L1 protein levels and observed a significant decrease in SKMel-5 and SKMel-28 cells (Figure 5c). Here, BCL2 is linked to melanoma.