Further studies showed that p53 transfection can reverse the anti-apoptotic action of ZNF143, while the p53-specific inhibitor pifithrin-α reduced the apoptotic influence of ZNF143, which might be based on the inhibition of ROS production in GC cells by P53 protein, thereby reducing the apoptotic effect of tumor cells. The gene discussed is TP53; the disease is neoplasm.