In GC, a large number of highly expressed C2H2-type ZFPs promote cell proliferation, specifically ZNF852, ZNF521, ZNF460, ZNF280B, ZNF143, zinc finger protein X-linked (ZFX), DAZ-interacting zinc finger protein 1 (DZIP1), E3 ubiquitin ligase ring finger protein 114 (RNF114) and pleomorphic adenoma gene like-2 (PLAGL2). This evidence concerns the gene ZNF280B and gastric cancer.