In GC, the C2H2-type TNFAIP3 can interact with RIP1 and DR4, and a low expression of TNFAIP3 can prevent the polyubiquitination of RIP1, promote the cleavage of caspase-8 and then inhibit DISC formation, eventually suppressing apoptosis [81]. This evidence concerns the gene TNFAIP3 and gastric cancer.