MZF1 can facilitate metastasis in GC via the miR-337-3p/MZF1/MMP-14 pathway [91], while impeding the invasion and metastasis of GC cells via the MT2A-NF-κB pathway [88], the MZF1-SMAD4 axis [87] or the MZF1/miR-328-3p/CD44 axis [89]. The gene discussed is SMAD4; the disease is gastric cancer.