The above provides a brief overview of the research progress on the relationship between ZFPs and GC nowadays, as well as the basic molecular mechanisms as seen through multiple biological processes, including cell proliferation, EMT, invasion and metastasis, inflammation and immune infiltration, apoptosis, cell cycle, DNA methylation, CSCs, drug resistance, etc. Significantly, we highlight the dual inverse role of MZF1 in GC. The gene discussed is MZF1; the disease is gastric cancer.