Amounts of C2H2-type ZNFs with a high expression which can trigger EMT, invasion and metastasis were found in GC, particularly ZNF521, ZNF460, ZNF143, zinc finger protein 139 (ZNF139), zinc finger and BTB domain-containing 20 (ZBTB20), Snail, DZIP1, Slug, RNF114, PLAGL2, GLI family zinc finger 1 (GLI1), Krüppel-like factor 8 (KLF8), CCCTC-binding factor (CTCF) and the E-box-binding protein ZEBs (ZEB1 and ZEB2), as illustrated in Figure 2. The gene discussed is RNF114; the disease is gastric cancer.