Moreover, when the ZNF852 is knocked down using the CRISPR/cas9 system in GC, its ability to reproduce is inhibited, along with the decreased expression of Nanog, SRY-box 2 (Sox2) and Oct4, meaning that ZNF852 preserves the self-renewal and tumor stem cell properties of GC [33]. This evidence concerns the gene SOX2 and neoplasm.