In GC, the upregulation of some ZNFs can increase the malignancy of GC via cell-cycle-related regulation such as ZNF139, ZFX, MORC2, GLI1, ZNF460, Krüppel-like factor 12 (KLF12) and Ring finger protein 2 (RNF2). This evidence concerns the gene RNF2 and gastric cancer.