Several ZFPs such as ZNF460, ZNF521, Snail, RNF114, ZEB1, ZNF139, ZFP64, GLIS2, GLI1, ZNF545, ZNF471, RNF180, ZIC1, zFOC1, ZBP89 and RNF43 are ascertained to have potential implications for prognosis prediction in GC and can be possibly used to monitor drug efficacy and the recurrence of GC. The gene discussed is RNF43; the disease is gastric cancer.