NFE2 and infection: M’s role in infection includes impacting the host nuclear-mitochondrial axis; effects at the nuclear chromatin/transcriptional level have strong effects on the host mitochondria, and in turn, induced ROS production by the mitochondria is likely to impact nuclear transcription through nuclear transcription factors, such as nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) [7,8,45,46].