Considering the role of TRPC5 in breast cancer chemoresistance [26] and the repeated use of Gd-DTPA in cancer patients, we investigated the effects of long-term Gd-DTPA or GDD treatment on the expression of TRPC5 in MCF-7, SK-BR-3, and MCF-7/ADM cells. Here, TRPC5 is linked to breast carcinoma.