Transcriptome profiling of neoplastic B-cell models overexpressing UGT2B17 (UGT2B17OE) and CLL patients with high UGT2B17 expression (UGT2B17HI) demonstrated a considerable transcriptional shift in genes regulating proliferation and survival signaling pathways (Figure 1). Here, UGT2B17 is linked to B-cell chronic lymphocytic leukemia.