Coherent with this concept, UGT2B17HI B-CLL patient cells displayed greater activation of SYK (1.3-fold; p = 0.03) (Figure 5G), as well as pSTAT6, that did not reach significance, compared to UGT2B17LOW CLL cases (Figure 5H,I). This evidence concerns the gene SYK and B-cell chronic lymphocytic leukemia.