Interestingly, HDL isolated from patients with type 2 diabetes or patients with cardiovascular disease had abolished the ability to stimulate eNOS activity and its ability to prevent NF-κB activation stimulated by tumor necrosis factor alpha was reduced in endothelial cells, while HDL isolated from healthy subjects activated the eNOS/NO pathway and reduced oxidative stress stimuli in endothelial cells [96]. Here, NOS3 is linked to cardiovascular disorder.