While increased accumulation of free cholesterol in hepatic stellate cells induces trans-differentiation into myofibrogenic phenotypes, which exacerbates liver fibrosis [126,127], LXRβ activation in hepatic stellate cells largely exerts antifibrogenic and anti-inflammatory properties [128], possibly preventing the progression to liver fibrosis. The gene discussed is NR1H2; the disease is Hepatic fibrosis.