In oral cancer, high expressions of ISG15, IFI27, and OASL were found to be associated with low ATM expression (mimicry of ATM inhibition), the activation of inflamed immune pathways, and elevated tumor-infiltrated scores of pDC, NK, and CD8+ T cells (Figure 6 and Figure 7, Table 1 and Table 2). This evidence concerns the gene ISG15 and neoplasm.