We explored the ability of a small molecule ((S)-2-acetamido-N-benzyl-3-methoxypropionamide, (S)-lacosamide, ((S)-LCM), which selectively suppresses CRMP2 phosphorylation at Ser 522 and Thr 509/514 by Cdk5 and GSK-3β kinases [39,40], to preserve CRMP2 interaction with its binding partners, prevent alterations in mitochondrial morphology and motility, and protect mouse AD neurons from cell death. Here, DPYSL2 is linked to Alzheimer disease.